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Kisspeptin: Mouse study shows how the brain controls sex Date: January 26, 2018 Source: Saarland University Summary: Kisspeptin has already been identified as the key molecule within the brain responsible for triggering puberty and controlling fertility. A new study in mice reveals that a subset of neurons in an evolutionarily ancient part of brain, the hypothalamus, drive both attraction to the opposite sex and sexual behavior by two independent mechanisms. Share: Using female mice as a model, the researchers found that a hormone in the brain, appropriately called kisspeptin, drives both attraction to the opposite sex and sexual behavior. They discovered that pheromones secreted by the male mouse activate these neurons which, in turn, transmit this signal to another population of neurons gonadotropin-releasing hormone neurons to drive attraction to the opposite sex. In parallel, they also transmit this signal to cells that produce the neurotransmitter nitric oxide to trigger sexual behavior. In many animals, sexual behavior is timed to occur with ovulation to ensure the highest possible chance of fertilization and therefore, continuation of the species. Until now, little was known about how the brain ties together ovulation, attraction and sex. Taken together, these findings show that puberty, fertility, attraction and sex are all controlled by a single molecule; kisspeptin. This work opens up new and exciting possibilities for the treatment of patients with psychosexual disorders such as hyposexual desire disorder. Female sex date saarland behavior in mice is controlled by kisspeptin neurons.
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